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High mileage is used to refer to a person who had intercourse with a lot of different individuals. Typically, it is used in the phrase 'high mileage ho.'
Generally, the term is used when describing high levels of intercourse in women. It refers to "pussy miles" in a comparable way to car mileage. The term can be used in reference to men, though it is not as common. It is used similarly to the word slut or whore.