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Safe sex refers to sexual activity in which both partners take precautions against contracting sexually transmitted diseases and unwanted pregnancy. Because sexual activity always carries some risk - both of pregnancy and of disease - many people now use the term "safer sex" to make this clear. That said, contraceptive measures like condoms and birth control pills can greatly reduce the risks involved.
STDs can be transmitted through anal, oral or vaginal sex. Any time bodily fluids are exchanged, it is possible to contract an STD. Barrier contraceptive methods such as condoms and dental dams are designed to reduce the risk of transmission. Barrier methods can also help to prevent pregnancy, but they are best combined with other methods such as birth control pills.