Epididymitis is an inflammation of the epididymis that is most often caused by bacteria infection including, but not limited to, sexually transmitted infections such as gonorrhea and chlamydia. Symptoms of epididymitis include swelling, redness, and warmth in the scrotum, pain and tenderness on one side of the testicles, painful and/or frequent urination, penile discharge, pain with ejaculation, enlargement of the lymph nodes, appearance of a lump on the testicle, lower abdomen/pelvic pain, blood in the semen, and, less often, fever.